Key result
Furosemide 80mg IV bolus did not significantly improve the subjective perception of dyspnoea compared to placebo at 1 hour in patients with hypertensive pulmonary oedema (median BORG 3 vs 3; P=0.40).
Why the study?
Does furosemide 80mg IV bolus improve subjective perception of dyspnoea in patients with pulmonary oedema because of hypertensive crisis?
Population
59 patients with pulmonary oedema because of hypertensive crisis.
Comparison
Furosemide 80mg IV bolus added to oxygen… vs Saline placebo added to oxygen…
Design
RCT, Randomized, Double-blinded
Follow-up
6 hours
Authors
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Does not support furosemide bolus for dyspnoea relief; challenges routine adjunctive diuretic use in hypertensive pulmonary oedema.
RCT (n=59)
Double-blind
Randomized
Yes
Does furosemide 80mg IV bolus improve subjective perception of dyspnoea in patients with pulmonary oedema because of hypertensive crisis?
Absolute Event Rate: 3% vs 3%
p-value: p=0.40
In patients with hypertensive pulmonary edema, the addition of an 80mg IV furosemide bolus to standard therapy did not improve the subjective perception of dyspnea at 1 hour.
Holzer‐Richling et al. (2010) conducted an RCT in pulmonary oedema because of hypertensive crisis (n=59). furosemide vs. saline placebo was evaluated on subjective perception of dyspnoea as measured with a modified BORG scale at one hour after randomization (p=0.40). Furosemide 80mg IV bolus did not significantly improve the subjective perception of dyspnoea compared to placebo at 1 hour in patients with hypertensive pulmonary oedema (median BORG 3 vs 3; P=0.40).
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