Key result
Intensive blood pressure lowering reduced the incidence of the composite outcome of atrial fibrillation and P-wave indices compared to standard therapy (HR 0.87; 95% CI 0.77-0.98; P=0.02).
Why the study?
Does intensive blood pressure lowering reduce incident atrial fibrillation and P-wave indices in patients with type 2 diabetes?
RCT (n=3,087)
Open-label
Randomized
Does intensive blood pressure lowering reduce incident atrial fibrillation and P-wave indices in patients with type 2 diabetes?
Effect estimate: HR 0.87 (95% CI 0.77-0.98)
Absolute Event Rate: 73.9% vs 84.5%
p-value: p=0.02
Intensive blood pressure lowering (target SBP <120 mm Hg) reduces the composite of incident atrial fibrillation and P-wave indices in patients with type 2 diabetes compared to standard lowering.
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Supports intensive SBP <120 mm Hg targets in type 2 diabetes to lower AF risk; extends BP-AF evidence to this population.
Chen et al. (2015) conducted an RCT in Type 2 diabetes (T2DM) (n=3,087). Intensive BP lowering vs. Standard BP lowering (SBP <140mm Hg) was evaluated on Composite of incident AF and PWI (HR 0.87, 95% CI 0.77-0.98, p=0.02). Intensive blood pressure lowering reduced the incidence of the composite outcome of atrial fibrillation and P-wave indices compared to standard therapy (HR 0.87; 95% CI 0.77-0.98; P=0.02).
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