Key result
Factor V Leiden links to deep vein thrombosis, but not to myocardial infarction.
Why the study?
Factor V Leiden G1691A and Factor II prothrombin G20210A mutations are leading causes of thrombophilia, but their prevalence among Libyan DVT and MI patients required investigation.
Are Factor V Leiden and Factor II prothrombin mutations associated with deep vein thrombosis or myocardial infarction in Libyan patients?
Case-Control (n=205)
Yes
Are Factor V Leiden and Factor II prothrombin mutations associated with deep vein thrombosis or myocardial infarction in Libyan patients?
p-value: p=0.03
In the Libyan population, the Factor V Leiden mutation is significantly associated with deep vein thrombosis but not myocardial infarction, whereas the prothrombin G20210A mutation is associated with neither.
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May support DVT-specific thrombophilia testing in Libyans; leaves open MI association and broader generalizability.
Msalati et al. (2021) conducted a case-control in Deep vein thrombosis and myocardial infarction (n=205). Factor V Leiden (G1691A) and Factor II prothrombin (G20210A) mutations vs. Wild type / Healthy controls was evaluated on Association of Factor V Leiden mutation with deep vein thrombosis (p=0.03). Factor V Leiden mutation was significantly associated with deep vein thrombosis (p=0.03) but not with myocardial infarction, while the prothrombin G20210A mutation was not associated with either condition in Libyan patients.
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