What does this research mean for the field?

Arachidonic acid and other cis-unsaturated fatty acids synergistically enhance the stimulatory effects of diacylglycerol on cardiomyocyte contraction and intracellular calcium transients via the activation of protein kinase C. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

July 1, 2000AJP Heart and Circulatory Physiology

Diacylglycerol and fatty acids synergistically increase cardiomyocyte contraction via activation of PKC

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Structured PICO

Population

Ventricular myocytes

Intervention

Combination of diacylglycerol analog dioctanoylglycerol (diC(8)) and cis-unsaturated fatty acids (UFA) such as arachidonic acid

Comparator

diC(8) alone or baseline

Outcome

Myocyte twitch amplitude and intracellular Ca(2+) transientssurrogate

Diacylglycerol and cis-unsaturated fatty acids act synergistically to increase cardiomyocyte contraction via activation of protein kinase C.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

May extend PKC synergy insights in isolated myocytes; leaves open human cardiac relevance.

Cite This Study

Pi et al. (2000) studied this question.

synapsesocial.com/papers/6a1c2f1b1567d2fc4d5fba04 https://doi.org/10.1152/ajpheart.2000.279.1.h26

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Diacylglycerol and fatty acids synergistically increase cardiomyocyte contraction via activation of PKC

Structured PICO

Discussion

Implication

Cite This Study

Diacylglycerol and fatty acids synergistically increase cardiomyocyte contraction via activation of PKC

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider