Why the study?
Does intracellular release of diacylglycerol analogue diC8 improve twitch amplitude in adult rat ventricular myocytes?
Does intracellular release of diacylglycerol analogue diC8 improve twitch amplitude in adult rat ventricular myocytes?
Intracellular release of diacylglycerol induces a strong positive inotropic effect in mammalian ventricular muscle, likely via protein kinase C activation.
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Intracellular diC8 boosts twitch force in rat myocytes; leaves open translation to intact mammalian hearts or clinical inotropy.
Pi et al. (1997) studied this question.
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