Key result
The 5' untranslated sequence of the capsid protein 2 gene of Mink Enteritis Virus regulates capsid gene expression and transcriptional activity of the P38 promoter.
The 5′ untranslated region of the capsid protein 2 gene in Mink Enteritis Virus is essential for regulating capsid gene expression, providing potential targets for vaccines and antiviral agents.
May inform MEV vaccine or antiviral design; leaves open translation beyond this animal model.
MEV, a parvovirus, causes acute enteritis in mink. In the present report, we describe an untranslated sequence-dependent mechanism by which MEV regulates capsid gene expression. Our results highlight the roles of untranslated sequences in regulating the transcriptional activity of P38 promoter and translation of capsid genes. These data also reveal the possibility of an unusual translation mechanism in capsid protein expression and the multiple functions of nonstructural protein. A better understanding of the gene expression regulation mechanism of this virus will help in the design of new vaccines and targets for antiviral agents against MEV.
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Yang et al. (2018) studied Mink enteritis. The 5' untranslated sequence of the capsid protein 2 gene of Mink Enteritis Virus regulates capsid gene expression and transcriptional activity of the P38 promoter.
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