Key result
Regular mild to moderate aerobic exercise demonstrated positive effects on aorta expansion, left ventricular dilation and hypertrophy, and aerobic capacity in Marfan syndrome patients.
Why the study?
The extent to which regular physical activity influences fatal manifestations of Marfan syndrome is sparsely described, and current physical training guidelines are based on limited research.
Does regular mild to moderate aerobic exercise improve aorta expansion and aerobic capacity in patients with Marfan syndrome?
Does regular mild to moderate aerobic exercise improve aorta expansion and aerobic capacity in patients with Marfan syndrome?
Regular mild to moderate aerobic exercise appears safe and potentially beneficial for aortic and ventricular parameters in Marfan syndrome, challenging historically conservative exercise guidelines.
May support cautious inclusion of mild-moderate aerobic exercise in Marfan syndrome care; leaves open prospective randomized confirmation.
Marfan syndrome (MFS) is an autosomal dominant condition caused by a mutation in the fibrillin-1–producing gene within the connective tissue, which can affect multiple organ systems negatively, including those that play a vital role (eg, heart and vasculature) in physical activity. The most fatal manifestations of MFS are aortic dilation, dissection, and rupture but to what extent regular physical activity will influence this is sparsely described. The current guidelines for MFS and physical training are based on limited research, and this review aims to summarize human and animal studies on exercise and its influence upon MFS presentation. Most studies found positive effects of regular mild to moderate aerobic exercise upon aorta expansion, as well as upon dilation and hypertrophy of the left ventricle together with a positive training response upon aerobic capacity. However, from the present studies, it is not possible to conclude regarding optimal intensity, frequency, duration, and type of exercise. Overall, the guidelines for exercise in MFS patients have so far due to limited research been relative conservative, despite the fact that at least moderate exercise in combination with tight cardiac monitoring does not demonstrate any detrimental effect upon MFS presentation.
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Jensen et al. (2020) conducted a review in Marfan syndrome. Regular mild to moderate aerobic exercise was evaluated on Aorta expansion, dilation and hypertrophy of the left ventricle, and aerobic capacity. Regular mild to moderate aerobic exercise demonstrated positive effects on aorta expansion, left ventricular dilation and hypertrophy, and aerobic capacity in Marfan syndrome patients.
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