Key result
Exercise recommendations for Marfan syndrome and inherited aortopathies lack outcomes data to guide clinical practice.
Current exercise recommendations for patients with Marfan syndrome and inherited aortopathies are based on theoretical reasoning rather than clinical outcomes data.
Exercise recommendations in Marfan syndrome lack outcomes data; leaves open the need for prospective trials to define safe activity.
Exercise recommendations for those who have Marfan syndrome or other genetic predisposition for thoracic aortic disease remain controversial and at times ambiguous. There are no outcomes studies to help guide recommendations. In this review, we examine the guidelines regarding exercise and inherited aortic conditions, the theoretical reasoning and circumstantial evidence that support the guidelines, as well as the knowledge gaps that continue to exist.
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Cheng et al. (2016) conducted a review in Marfan syndrome or other genetic predisposition for thoracic aortic disease. Exercise was evaluated. Exercise recommendations for patients with Marfan syndrome or inherited aortopathies remain controversial due to a complete lack of outcomes studies to guide clinical practice.
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