What does this research mean for the field?

Hypertrophic cardiomyopathy frequently exhibits familial occurrence with an autosomal dominant pattern of inheritance, and affects males significantly more often than females. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This study aims to determine how hypertrophic cardiomyopathy is inherited among family members of affected individuals.

September 1, 1987HeartOpen Access

Inheritance of hypertrophic cardiomyopathy: a cross sectional and M mode echocardiographic study of 50 families.

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Why the study?

What is the mode of inheritance and prevalence of hypertrophic cardiomyopathy among first-degree relatives of affected patients?

Population

193 first degree relatives (parents, siblings, and offspring) of 50 patients with hypertrophic cardiomyopathy

Design

Cross-sectional

Authors

SGSally GreavesAuckland City Hospital ARA RocheUniversity of Arizona JNJohn M. NeutzeBoston Children's Hospital

Discussion

Member takes

Implication

May support relative screening in HCM; leaves open prospective confirmation of prevalence and inheritance.

Key Points

This study aims to determine how hypertrophic cardiomyopathy is inherited among family members of affected individuals.
Assessed 193 first degree relatives of 50 patients with hypertrophic cardiomyopathy.
Used clinical examinations, electrocardiography, M mode, and cross-sectional echocardiography for assessments.
Examined familial occurrence patterns, particularly in families with multiple affected members.
20% of first degree relatives were found to have hypertrophic cardiomyopathy; 37% of parents, 25% of siblings, and 8% of offspring were affected.
Statistically significant difference observed between affected males (43%) and females (30%).
15 families showed autosomal dominant inheritance patterns, while other families had ambiguous inheritance classifications.

Structured PICO

What is the mode of inheritance and prevalence of hypertrophic cardiomyopathy among first-degree relatives of affected patients?

Population

193 first degree relatives (parents, siblings, and offspring) of 50 patients with hypertrophic cardiomyopathy

Intervention

Clinical examination, electrocardiography, M mode and cross sectional echocardiography, and necropsy

Outcome

Mode of inheritance and prevalence of hypertrophic cardiomyopathy among first-degree relatives

The study demonstrates that hypertrophic cardiomyopathy frequently exhibits familial occurrence consistent with an autosomal dominant trait, highlighting the importance of echocardiographic screening for first-degree relatives.

Cite This Study

Greaves et al. (1987) studied this question.

synapsesocial.com/papers/6a1c4812d54006be995fcfbc https://doi.org/10.1136/hrt.58.3.259

Topics

Echocardiography Hypertrophic cardiomyopathy

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Inheritance of hypertrophic cardiomyopathy: a cross sectional and M mode echocardiographic study of 50 families.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Inheritance of hypertrophic cardiomyopathy: a cross sectional and M mode echocardiographic study of 50 families.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider