Key result
Young first-degree relatives of patients with familial hypertrophic cardiomyopathy without echocardiographic evidence of the disease had significantly greater Qz amplitude and Q/Rz ratio than controls.
Why the study?
Does vectorcardiographic analysis identify abnormal anterior forces in echocardiographically unaffected first-degree relatives of patients with familial hypertrophic cardiomyopathy?
Population
38 subjects from 4 families with familial hypertrophic cardiomyopathy, and 38 normal control subjects.
Comparison
Electrocardiographic and vectorcardiographic… vs Normal control subjects of comparable age range
Design
Cross-sectional
Authors
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Vectorcardiography may flag preclinical changes in at-risk relatives; leaves open its screening utility pending prospective validation.
Cross-Sectional (n=76)
Does vectorcardiographic analysis identify abnormal anterior forces in echocardiographically unaffected first-degree relatives of patients with familial hypertrophic cardiomyopathy?
Abnormal anterior forces on vectorcardiography may help identify genetic transmission of familial hypertrophic cardiomyopathy in relatives before echocardiographic evidence appears.
Loperfido et al. (1982) conducted a cross-sectional in Familial hypertrophic cardiomyopathy (n=76). First-degree relative of patient with familial hypertrophic cardiomyopathy vs. Normal control subjects was evaluated on Qz amplitude and Q/Rz ratio on vectorcardiogram. Young first-degree relatives of patients with familial hypertrophic cardiomyopathy without echocardiographic evidence of the disease had significantly greater Qz amplitude and Q/Rz ratio than controls.
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