Key result
A febrile state with marked leukocytosis unmasked the electrocardiographic pattern of Brugada syndrome in a reported clinical case.
Fever and marked leukocytosis can unmask the Brugada electrocardiographic pattern, highlighting the temperature dependence of sodium channels.
ECG monitoring prudent in febrile leukocytosis; case report leaves open need for systematic validation.
Several agents and conditions have been reported to unmask or accentuate the electrocardiographic pattern of Brugada syndrome including fever. At a molecular level, sodium channels have been showed to be temperature dependent. Herein, we describe a case of Brugada electrocardiographic pattern unmasked during febrile state and marked leukocytosis.
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Gavrielatos et al. (2007) studied this question. A febrile state with marked leukocytosis unmasked the electrocardiographic pattern of Brugada syndrome in a reported clinical case.
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