Inefficient functional sympatholysis is an overlooked cause of malperfusion in contracting skeletal muscle
Key result
Regular physical activity prevents age-related impairments in functional sympatholysis and normalizes reduced exercise hyperaemia in patients with essential hypertension.
Design
Review
Authors
Discussion
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Member takes
Implication
Supports activity to maintain perfusion in hypertension; leaves open randomized outcome trials.
PICO
P
Population
Impaired functional sympatholysis
I
Intervention / Comparator
Physical activity vs Sedentary lifestyle
O
Primary Outcome
Functional sympatholysis and muscle blood flow
Physical activity is crucial for maintaining and restoring functional sympatholysis in skeletal muscle, which is impaired by aging, immobilization, and essential hypertension.
Limitations
- It remains uncertain which locally released substance(s) block the effect of noradrenaline and how this is accomplished.
Cite This Study
Saltin et al. (2012) conducted a review in Impaired functional sympatholysis. Physical activity vs. Sedentary lifestyle was evaluated on Functional sympatholysis and muscle blood flow. Regular physical activity prevents age-related impairments in functional sympatholysis and normalizes reduced exercise hyperaemia in patients with essential hypertension.