Key result
Adenosine transporter antagonism with dipyridamole augmented vasodilator responsiveness to exogenous adenosine in both responders and non-responders (P<0.001), but had no effect on exercise hyperemia.
Why the study?
Does adenosine transporter antagonism with dipyridamole augment vasodilator responsiveness to adenosine and exercise in humans?
Population
20 human subjects, categorized as adenosine (ADO) responders and non-responders
Comparison
Infusion of dipyridamole (DIP) vs Before infusion of dipyridamole
Authors
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Indicates insufficient adenosine rise during exercise to drive hyperemia; hypothesis-generating for vascular control mechanisms.
Does adenosine transporter antagonism with dipyridamole augment vasodilator responsiveness to adenosine and exercise in humans?
p-value: p=<0.001
Adenosine transporter blockade with dipyridamole augments adenosine-mediated vasodilation in non-responders but does not affect exercise hyperemia, suggesting adenosine concentrations do not rise sufficiently during rhythmic handgripping to impact these responses.
Martin et al. (2006) studied this question. Adenosine (ADO) and dipyridamole (DIP) infusion vs. Baseline (before dipyridamole infusion) was evaluated on Forearm vascular conductance (FVC) during infusion of ADO and during handgripping (p=<0.001). Adenosine transporter antagonism with dipyridamole augmented vasodilator responsiveness to exogenous adenosine in both responders and non-responders (P<0.001), but had no effect on exercise hyperemia.
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