What question did this study set out to answer?

This research aims to evaluate the effectiveness of low molecular weight heparin compared to standard heparin in treating deep venous thrombosis.

January 1, 1985Thrombosis and Haemostasis

A Comparison Between Low Molecular Weight Heparin (KABI 2165) and Standard Heparin in the Intravenous Treatment of Deep Venous Thrombosis

Q: What does this research mean for the field?

Low molecular weight heparin demonstrates similar efficacy to standard unfractionated heparin in the intravenous treatment of deep venous thrombosis, though high initial doses can lead to major bleeding complications. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

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Why the study?

Does continuous intravenous infusion of low molecular weight heparin improve thrombus size compared to unfractionated heparin in patients with deep venous thrombosis?

Key Points

This research aims to evaluate the effectiveness of low molecular weight heparin compared to standard heparin in treating deep venous thrombosis.
Patients with DVT were randomized to receive either LMWH or UFH via intravenous infusion.
Two studies were conducted; the first used higher doses for LMWH, while the second used lower doses.
Heparin activity was measured as anti F Xa inhibition, with phlebographic evaluations conducted for thrombus size.
In study I, no DVT patients treated with LMWH showed thrombus size progression vs. 11% in UFH group.
In study II, 77% of LMWH patients improved vs. UFH's 48%.
Significant decrease in antithrombin III was observed in the UFH group but not in LMWH.

Structured PICO

Does continuous intravenous infusion of low molecular weight heparin improve thrombus size compared to unfractionated heparin in patients with deep venous thrombosis?

Population

54 patients with deep venous thrombosis (DVT) verified by phlebography (27 in study I, 27 in study II).

Intervention

Low molecular weight heparin (LMWH, KABI 2165) continuous intravenous infusion (initial dose 240 U/kg/12 h in study I, 120 U/kg/12 h in study II).

Comparator

Unfractionated heparin (UFH) continuous intravenous infusion (initial dose 240 U/kg/12 h).

Outcome

Change in thrombus size on second phlebography (progression, improvement, or mean decrease of thrombus size score according to Marder).surrogate

Intravenous low molecular weight heparin appears to have similar efficacy to unfractionated heparin in treating deep venous thrombosis, though high initial doses caused major bleeding in post-operative patients.

Limitations

Small sample size

Authors

GBGöran BrattKarolinska Institutet ETE. TörnebohmStockholm University College of Music Education SGS. GranqvistErsta sjukhus

Discussion

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Implication

Supports continuous IV LMWH as alternative to UFH in DVT; confirms similar thrombus size outcomes.

Cite This Study

Bratt et al. (1985) studied this question.

synapsesocial.com/papers/6a1c57b31567d2fc4d5ff647 https://doi.org/10.1055/s-0038-1660139

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A Comparison Between Low Molecular Weight Heparin (KABI 2165) and Standard Heparin in the Intravenous Treatment of Deep Venous Thrombosis

Key Points

Structured PICO

Limitations

Discussion

Implication

Cite This Study

A Comparison Between Low Molecular Weight Heparin (KABI 2165) and Standard Heparin in the Intravenous Treatment of Deep Venous Thrombosis

Key Points

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Also Consider

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