Key result
Global longitudinal active strain energy density was progressively reduced in hypertension, dilated cardiomyopathy, and cardiac amyloidosis (0.42 kJ/m3) compared to healthy controls (1.94 kJ/m3).
Why the study?
Left ventricular ejection fraction does not accurately predict exercise capacity, symptom severity, or prognosis in heart failure, creating a need for better measures of ventricular performance.
Does global longitudinal active strain energy density (GLASED) provide a better measure of left ventricular systolic function compared to standard ejection fraction across different cardiac pathologies?
Cross-Sectional (n=183)
Single-blind
Does global longitudinal active strain energy density (GLASED) provide a better measure of left ventricular systolic function compared to standard ejection fraction across different cardiac pathologies?
GLASED is a novel, biomechanically derived measure of left ventricular systolic function that can detect severe myocardial impairment even when ejection fraction is relatively preserved, such as in cardiac amyloidosis.
GLASED may detect systolic impairment missed by ejection fraction; hypothesis-generating and requires prospective validation.
The left ventricular ejection fraction does not accurately predict exercise capacity or symptom severity and has a limited role in predicting prognosis in heart failure. A better method of assessing ventricular performance is needed to aid understanding of the pathophysiological mechanisms and guide management in conditions such as heart failure. In this study, we propose two novel measures to quantify myocardial performance, the global longitudinal active strain energy (GLASE) and its density (GLASED) and compare them to existing measures in normal and diseased left ventricles. GLASED calculates the work done per unit volume of muscle (energy density) by combining information from myocardial strain and wall stress (contractile force per unit cross sectional area). Magnetic resonance images were obtained from 183 individuals forming four cohorts (normal, hypertension, dilated cardiomyopathy, and cardiac amyloidosis). GLASE and GLASED were compared with the standard ejection fraction, the corrected ejection fraction, myocardial strains, stroke work and myocardial forces. Myocardial shortening was decreased in all disease cohorts. Longitudinal stress was normal in hypertension, increased in dilated cardiomyopathy and severely decreased in amyloid heart disease. GLASE was increased in hypertension. GLASED was mildly reduced in hypertension (1.39 ± 0.65 kJ/m 3 ), moderately reduced in dilated cardiomyopathy (0.86 ± 0.45 kJ/m 3 ) and severely reduced in amyloid heart disease (0.42 ± 0.28 kJ/m 3 ) compared to the control cohort (1.94 ± 0.49 kJ/m 3 ). GLASED progressively decreased in the hypertension, dilated cardiomyopathy and cardiac amyloid cohorts indicating that mechanical work done and systolic performance is severely reduced in cardiac amyloid despite the relatively preserved ejection fraction. GLASED provides a new technique for assessing left ventricular myocardial health and contractile function.
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MacIver et al. (2022) conducted a cross-sectional in Left ventricular systolic dysfunction (n=183). Global longitudinal active strain energy density (GLASED) vs. Healthy controls was evaluated on Global longitudinal active strain energy density (GLASED) in cardiac amyloidosis (p=<0.0001). Global longitudinal active strain energy density was progressively reduced in hypertension, dilated cardiomyopathy, and cardiac amyloidosis (0.42 kJ/m3) compared to healthy controls (1.94 kJ/m3).
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