Key result
Guidewire insertion in in vitro coronary stenosis models significantly reduced flow and increased trans-stenotic pressure drop, underestimating true FFR (FFR=0.92×gFFR+0.097; R2=0.99).
Why the study?
Does guidewire insertion alter trans-stenotic pressure drop, FFR, and CFR in in vitro model coronary stenoses?
Does guidewire insertion alter trans-stenotic pressure drop, FFR, and CFR in in vitro model coronary stenoses?
Effect estimate: R2=0.99
Guidewire insertion during FFR and CFR measurements causes a flow-obstruction effect that underestimates true values, which can be corrected using derived mathematical correlations.
No takes yet. Share an insight, caveat, or question.
May bias clinical FFR interpretation; leaves open in vivo validation of correction models.
Ashtekar et al. (2007) studied Coronary stenosis. Guidewire insertion (0.35mm diameter) vs. True physiological measurements (without guidewire) was evaluated on Trans-stenotic pressure drop, fractional flow reserve (FFR), and coronary flow reserve (CFR) (R2=0.99). Guidewire insertion in in vitro coronary stenosis models significantly reduced flow and increased trans-stenotic pressure drop, underestimating true FFR (FFR=0.92×gFFR+0.097; R2=0.99).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: