Modulation by calcium of the potassium permeability of dog heart sarcolemmal vesicles.
Population
Dog heart sarcolemmal vesicles
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Hypothesis-generating for Ca2+-activated K+ pathways in cardiac membranes; leaves open physiological role and translational relevance.
Structured PICO
P
Population
Dog heart sarcolemmal vesicles
I
Intervention
Calcium (5-50 microM) and inhibitors (tetraethylammonium ion, quinidine, trifluoperazine)
O
Outcome
Potassium (K+) and Rubidium (86Rb+) efflux/permeabilitysurrogate
Calcium stimulates potassium permeability in dog heart sarcolemmal vesicles, an effect inhibited by quinidine and trifluoperazine but not tetraethylammonium.
Cite This Study
Caroni et al. (1982) studied this question.