Key result
Right-sided transcutaneous auricular vagus nerve stimulation increased stomach-brain coupling in the nucleus of the solitary tract and midbrain, mirroring subjective hunger ratings.
Why the study?
A gastric network in the brain phase synchronized with stomach rhythm is established, but tools to perturb its function were lacking.
Does acute right-sided transcutaneous auricular vagus nerve stimulation improve stomach-brain coupling in unspecified subjects?
Comparison
Acute right-sided transcutaneous auricular vagus nerve stimulation (taVNS) vs sham stimulation
Design
Randomized crossover-design
Authors
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taVNS may modulate appetite via NTS-midbrain coupling; extends preclinical mechanisms to humans and supports targeted neuromodulation trials.
RCT
Crossover
Does acute right-sided transcutaneous auricular vagus nerve stimulation improve stomach-brain coupling in unspecified subjects?
Transcutaneous vagus nerve stimulation increases stomach-brain coupling via an NTS-midbrain pathway, which correlates with subjective hunger ratings and may offer novel neuromodulatory treatments.
Müller et al. (2021) reported an RCT. Right-sided transcutaneous auricular vagus nerve stimulation (taVNS) vs. Sham stimulation was evaluated on Stomach-brain coupling. Right-sided transcutaneous auricular vagus nerve stimulation increased stomach-brain coupling in the nucleus of the solitary tract and midbrain, mirroring subjective hunger ratings.
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