What does this research mean for the field?

Preoperative antibiotic prophylaxis with cefoxitin significantly reduces the incidence of wound infection in patients undergoing appendectomy for nonperforated appendicitis, but does not influence intra-abdominal abscess formation. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

March 1, 1989Annals of SurgeryOpen Access

Antibiotic Prophylaxis in Acute Nonperforated Appendicitis

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Why the study?

Does preoperative cefoxitin reduce wound infection in patients undergoing appendectomy?

Population

1735 evaluable patients undergoing appendectomy

Comparison

Cefoxitin 2 g administered preoperatively vs Control group

Design

RCT, block-randomized

Authors

TBTorben BauerUniversity of Copenhagen BVB VennitsRoskilde Sygehus BHB Holm

Discussion

Member takes

Implication

Supports routine preoperative cefoxitin prophylaxis in appendectomy; reinforces RCT evidence for surgical site infection prevention.

Structured PICO

Does preoperative cefoxitin reduce wound infection in patients undergoing appendectomy?

Population

1735 evaluable patients undergoing appendectomy (divided into groups with normal, acutely inflamed, and gangrenous appendix)

Intervention

Cefoxitin 2 g administered preoperatively

Comparator

Control group (implied no prophylaxis, as half of the patients received cefoxitin)

Outcome

Incidence of wound infectionhard clinical

Routine preoperative prophylaxis with cefoxitin significantly reduces wound infection rates in patients undergoing appendectomy.

Cite This Study

Bauer et al. (1989) studied this question.

synapsesocial.com/papers/6a1c73320e2acd31eb2fc656 https://doi.org/10.1097/00000658-198903000-00010

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Antibiotic Prophylaxis in Acute Nonperforated Appendicitis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Antibiotic Prophylaxis in Acute Nonperforated Appendicitis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider