Key result
Sustained VF requires left ventricular tissue volume to exceed critical three-dimensional wavelength volume.
Why the study?
Current QT toxicity analysis does not account for anisotropic cardiac tissue conductivity and its role in ventricular fibrillation inducibility is unclear.
Does 3-dimensional cardiac wavelength accurately predict ventricular fibrillation sustainability in human left ventricular preparations?
Population
Explanted human left ventricular wedge preparations from 14 donor hearts
Comparison
Pharmacologically induced shortening and prolongation of action potential duration using pinacidil vs glybenclamide vs baseline
Design
Panoramic optical mapping with S1S1 pacing protocol, nonrandomized, not blinded preclinical study
Authors
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Ex vivo findings support wavelength-volume thresholds for sustained VF in human myocardium; leaves open in vivo validation and clinical translation.
Does 3-dimensional cardiac wavelength accurately predict ventricular fibrillation sustainability in human left ventricular preparations?
p-value: p=<0.0001
Sustained ventricular fibrillation requires a ventricular tissue volume exceeding a critical 3-dimensional wavelength volume, highlighting the importance of anisotropic cardiac tissue conductivity in arrhythmia sustainability.
Aras et al. (2018) studied Ventricular fibrillation (n=30). Pinacidil and glybenclamide vs. Baseline conditions was evaluated on Inducibility of sustained ventricular fibrillation based on tissue volume to wavelength volume ratio (p=<0.0001). Sustained ventricular fibrillation was only inducible in human left ventricular tissue when the tissue volume exceeded the critical three-dimensional wavelength volume.
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