What question did this study set out to answer?

This research aims to understand how ionic and molecular dysfunction contributes to arrhythmogenesis in heart failure through transmural heterogeneities.

August 26, 2003Circulation ResearchOpen Access

Transmural Electrophysiological Heterogeneities Underlying Arrhythmogenesis in Heart Failure

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Why the study?

Does heart failure increase transmural heterogeneities of repolarization and susceptibility to polymorphic ventricular tachycardia in a canine model?

Population

Arterially perfused canine wedge preparations from dogs without and with heart failure produced by rapid…

Comparison

Heart failure model vs Control dogs without heart failure

Design

Preclinical

Authors

FAFadi G. AkarElectrophysiology DRDavid RosenbaumGeneral Cardiology

Discussion

Member takes

Implication

Repolarization gradients may drive PVT in HF; leaves open clinical translation from this canine model.

Key Points

This research aims to understand how ionic and molecular dysfunction contributes to arrhythmogenesis in heart failure through transmural heterogeneities.
Optical action potentials were measured from transmural wall cells in canine wedge preparations.
Wedges were isolated from dogs with heart failure (n=8) and controls (n=5) after inducing heart failure by rapid ventricular pacing.
Analysis focused on action potential duration and spatial gradients of repolarization across the ventricular wall.
In heart failure, action potential duration (APD) prolongation was significantly heterogeneous, particularly in midmyocardial cells.
APD prolongation of midmyocardial cells led to significant increases in spatial gradients of repolarization (12.4+/-3.5 ms/mm in HF vs 4.3+/-2.1 in controls, P<0.01).
Functional conduction block occurred in 63% of HF conditions, whereas no events were noted in controls (P<0.03).

Structured PICO

Does heart failure increase transmural heterogeneities of repolarization and susceptibility to polymorphic ventricular tachycardia in a canine model?

Population

Arterially perfused canine wedge preparations from dogs without (control, n=5) and with heart failure (n=8) produced by rapid ventricular pacing

Intervention

Heart failure model (produced by rapid ventricular pacing)

Comparator

Control dogs without heart failure

Outcome

Action potential duration (APD) and spatial gradients of repolarization across the ventricular wallsurrogate

In a canine model, heart failure causes selective prolongation of action potential duration in midmyocardial cells, increasing transmural repolarization gradients and susceptibility to polymorphic ventricular tachycardia.

Cite This Study

Akar et al. (2003) studied this question.

synapsesocial.com/papers/6a1e6c3240bc8a3dd768de5c https://doi.org/10.1161/01.res.0000092248.59479.ae

Topics

Heart failure HFrEF treatment

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Transmural Electrophysiological Heterogeneities Underlying Arrhythmogenesis in Heart Failure

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Transmural Electrophysiological Heterogeneities Underlying Arrhythmogenesis in Heart Failure

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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