August 20, 2005AJP Heart and Circulatory Physiology
Increased ventricular repolarization heterogeneity in patients with ventricular arrhythmia vulnerability and cardiomyopathy: a human in vivo study
Key result
Patients with cardiomyopathy and VT/TWA had significantly greater endocardial (P<0.005) and epicardial (P<0.05) repolarization heterogeneity than those without VT/TWA.
Why the study?
Is ventricular repolarization heterogeneity greater in cardiomyopathy patients with ventricular arrhythmia vulnerability compared to those without?
Population
22 patients with cardiomyopathy, including 12 with ventricular arrhythmia vulnerability and 10 without.
Design
Cross-sectional
Authors
Discussion
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Implication
May signal reentrant substrate in cardiomyopathy; hypothesis-generating, needs prospective validation before clinical use.
Study Design
Type
Observational (n=22)
Structured PICO
Is ventricular repolarization heterogeneity greater in cardiomyopathy patients with ventricular arrhythmia vulnerability compared to those without?
P
Population
22 patients with cardiomyopathy, evaluated for repolarization heterogeneity based on the presence (n=12) or absence (n=10) of ventricular arrhythmia vulnerability.
O
Outcome
Endocardial and epicardial repolarization heterogeneity (measured by local activation times, activation-recovery intervals, and repolarization times)surrogate
Main Result
p-value: p=<0.005
Patients with cardiomyopathy and ventricular arrhythmia vulnerability exhibit greater endocardial and epicardial repolarization heterogeneity, providing a potential substrate for reentrant arrhythmias.
Cite This Study
Chauhan et al. (2005) conducted an observational in Cardiomyopathy and ventricular arrhythmia vulnerability (n=22). Ventricular arrhythmia vulnerability (VT/TWA) vs. No ventricular arrhythmia vulnerability (no VT/TWA) was evaluated on Endocardial and epicardial repolarization time (RT) dispersion (p=<0.005). Patients with cardiomyopathy and VT/TWA had significantly greater endocardial (P<0.005) and epicardial (P<0.05) repolarization heterogeneity than those without VT/TWA.