November 14, 2006AJP Heart and Circulatory Physiology
Steeper restitution slopes across right ventricular endocardium in patients with cardiomyopathy at high risk of ventricular arrhythmias
Why the study?
Are right ventricular endocardial ARI restitution slopes steeper in cardiomyopathy patients at high risk for ventricular arrhythmias compared to those at low risk?
Population
18 patients with cardiomyopathy and no history of ventricular arrhythmias, stratified into high-risk and…
Comparison
High risk of ventricular arrhythmias vs Low risk of ventricular arrhythmias
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Steeper RV endocardial ARI slopes were associated with higher arrhythmia risk in cardiomyopathy; hypothesis-generating and requires prospective validation.
Structured PICO
Are right ventricular endocardial ARI restitution slopes steeper in cardiomyopathy patients at high risk for ventricular arrhythmias compared to those at low risk?
P
Population
18 patients with cardiomyopathy (LVEF <40%) and no history of ventricular arrhythmias, stratified into high-risk (n=8) and low-risk (n=10) groups based on programmed electrical stimulation or T wave alternans.
I
Intervention
High risk of ventricular arrhythmias (inducible VT or positive TWA)
C
Comparator
Low risk of ventricular arrhythmias (no inducible VT or negative TWA)
O
Outcome
Mean activation recovery interval (ARI) restitution slope from 10 right ventricular endocardial sites during an S1-S2 pacing protocolsurrogate
In patients with cardiomyopathy, steeper ARI restitution slopes across the right ventricular endocardium are associated with a higher risk of ventricular arrhythmias.
Cite This Study
Selvaraj et al. (2006) studied this question.