Maintenance of cardiac output with normal filling pressures in patients with dilated heart failure.
Why the study?
Does vasodilator and diuretic therapy reduce ventricular filling pressures without compromising cardiac output in patients with severe dilated heart failure?
Population
25 patients with dilated heart failure, severe symptoms, and ejection fractions of 25% or less
Comparison
Vasodilator and diuretic therapy titrated to… vs Baseline (pre-treatment hemodynamics)
Design
Case_series
Authors
Discussion
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Implication
Reducing filling pressures may be feasible without output compromise in severe HF; leaves open whether this improves outcomes in prospective trials.
Structured PICO
Does vasodilator and diuretic therapy reduce ventricular filling pressures without compromising cardiac output in patients with severe dilated heart failure?
P
Population
25 patients with dilated heart failure, severe symptoms, and ejection fractions of 25% or less
I
Intervention
Vasodilator and diuretic therapy titrated to achieve the lowest ventricular filling pressures
C
Comparator
Baseline (pre-treatment hemodynamics)
O
Outcome
Maintenance of cardiac output (stroke volume and stroke work index) at the lowest achieved ventricular filling pressuressurrogate
Normal filling pressures can be achieved with vasodilators and diuretics in severe dilated heart failure without compromising cardiac output.
Limitations
- Feasibility and benefit of maintaining normal filling pressures over a long term must be established
Cite This Study
Stevenson et al. (1986) studied this question.