Impact of Interatrial Shunts on Invasive Hemodynamics and Exercise Tolerance in Patients With Heart Failure
Why the study?
Pharmacologic therapies have been limited in reducing symptoms or improving outcomes in HFpEF, prompting exploration of interatrial shunts to reduce elevated left-sided filling pressures.
Does interatrial shunt implantation improve invasive hemodynamics and exercise tolerance in patients with heart failure with preserved ejection fraction?
Design
Review
Authors
Discussion
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Member takes
Implication
Should not yet change HFpEF management; leaves open whether interatrial shunts improve symptoms or prognosis beyond hemodynamics.
Structured PICO
Does interatrial shunt implantation improve invasive hemodynamics and exercise tolerance in patients with heart failure with preserved ejection fraction?
P
Population
Patients with heart failure with preserved ejection fraction (HFpEF)
I
Intervention
Interatrial shunt implantation
O
Outcome
Invasive hemodynamics (pulmonary capillary wedge pressure) and exercise tolerancesurrogate
Interatrial shunts may provide a novel device-based approach to lower exercise-induced pulmonary capillary wedge pressure in patients with HFpEF.
Cite This Study
Griffin et al. (2020) studied this question.