Key result
Cardiac sympathetic denervation in patients with refractory VT or electrical storm was associated with a 60% VT nonrecurrence rate and a reduction of 3.01 mean ICD shocks per person (P=0.002).
Why the study?
Cardiac sympathetic denervation is used for refractory VT and electrical storm, but data on its role in managing ventricular arrhythmia remain limited.
Does cardiac sympathetic denervation reduce VT recurrence and ICD shocks in patients with refractory VT or electrical storm?
Population
311 patients with refractory VT or electrical storm across 14 nonrandomized studies
Comparison
Outcomes before and after CSD
Design
Meta-analysis of retrospective studies
Follow-up
Mean 15 ± 10.7 months
Authors
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May warrant consideration for refractory VT; leaves open confirmation in randomized trials.
Meta-Analysis (n=311)
Does cardiac sympathetic denervation reduce VT recurrence and ICD shocks in patients with refractory VT or electrical storm?
Effect estimate: Mean difference -3.01 (95% CI 1.09-4.94)
p-value: p=.002
Cardiac sympathetic denervation is associated with a 60% freedom from VT and a significant reduction in ICD shocks in patients with refractory VT or electrical storm.
Murtaza et al. (2020) conducted a meta-analysis in Refractory ventricular tachycardia (VT) or electrical storm (n=311). Cardiac sympathetic denervation (CSD) vs. Before CSD was evaluated on Freedom from VT and standard mean difference of ICD shocks before and after CSD (Mean difference -3.01, 95% CI 1.09-4.94, p=.002). Cardiac sympathetic denervation in patients with refractory VT or electrical storm was associated with a 60% VT nonrecurrence rate and a reduction of 3.01 mean ICD shocks per person (P=0.002).
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