May 10, 2022EP Europace
Outcomes following cardiac sympathetic denervation in patients with structural heart disease and refractory ventricular arrhythmia
Key result
Cardiac sympathetic denervation in patients with refractory ventricular arrhythmias resulted in 76.9% of surviving patients being free from ICD shocks at a mean follow-up of 9.1 months.
Why the study?
Cardiac sympathetic denervation has been introduced as bailout therapy for structural heart disease and refractory ventricular arrhythmias, but available data remain scarce.
Does cardiac sympathetic denervation improve freedom from ventricular arrhythmias and ICD shocks in patients with structural heart disease and refractory ventricular arrhythmia?
Comparison
Cardiac sympathetic denervation via video-assisted thoracoscopic surgery
Design
Retrospective observational study
Follow-up
Mean duration 9.1 ± 6.5 months
Authors
Discussion
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Member takes
Implication
Caution against routine adoption from retrospective data; leaves open need for randomized trials of sympathetic denervation.
Study Design
Type
Observational (n=21)
Multicenter
No
Structured PICO
Does cardiac sympathetic denervation improve freedom from ventricular arrhythmias and ICD shocks in patients with structural heart disease and refractory ventricular arrhythmia?
P
Population
21 adult men with structural heart disease and refractory ventricular arrhythmias who underwent cardiac sympathetic denervation, followed for a mean of 9.1 months.
E
Exposure
Cardiac sympathetic denervation (CSD) via video-assisted thoracoscopic surgery (90.5% bilateral, 9.5% left-sided only) as bailout therapy.
O
Outcome
Immediate results, complications, and mid-term outcomes (freedom from any VA or ICD shocks) at mean 9.1 months follow-up.hard clinical
Cardiac sympathetic denervation provides moderate efficacy as a bailout therapy for suppressing refractory ventricular arrhythmias after unsuccessful catheter ablation, though it carries a risk of complications in a highly comorbid population.
Cite This Study
König et al. (2022) conducted an observational in structural heart disease and refractory ventricular arrhythmia (n=21). Cardiac sympathetic denervation was evaluated on freedom from ICD shocks among surviving patients. Cardiac sympathetic denervation in patients with refractory ventricular arrhythmias resulted in 76.9% of surviving patients being free from ICD shocks at a mean follow-up of 9.1 months.