Key result
Patients with rheumatic mitral stenosis had significantly higher mean platelet volume compared to healthy subjects (10.07 vs 8.15 fL, p < 0.001).
Why the study?
Is mean platelet volume increased in patients with rheumatic mitral stenosis compared to healthy subjects?
Cross-Sectional (n=116)
No
Is mean platelet volume increased in patients with rheumatic mitral stenosis compared to healthy subjects?
Absolute Event Rate: 10.07% vs 8.15%
p-value: p=<0.001
Patients with rheumatic mitral stenosis exhibit increased mean platelet volume, with severe mitral regurgitation and left atrial spontaneous echo contrast acting as significant predictors of platelet enlargement.
May indicate platelet activation in rheumatic mitral stenosis; leaves open utility for thromboembolic risk prediction.
BACKGROUND AND AIM: The aim of this study was to investigate mean platelet volume (MPV) in patients with rheumatic mitral stenosis (RMS) and to define the determinants of a possible platelet activation reflected as platelet volume enlargement. METHODS: Peripheral venous plasma value of MPV was measured in 84 consecutive patients (16 men, 68 women; mean age ± SD = 44 ± 13 years) with RMS who had no left atrial thrombus by transoesophageal echocardiography. The control group consisted of 32 healthy subjects (nine men, 23 women; mean age ± SD = 38 ± 7 years). RESULTS: The patients had significantly higher MPV values (mean ± SD = 10.07 ± 0.58 fL) compared to the healthy subjects (mean ± SD = 8.15 ± 0.60 fL, p < 0.001). Among many clinical and echocardiographic variables, left atrial spontaneous echo contrast-positivity (beta = 0.426, p < 0.001) and severe mitral regurgitation (beta = 0.577, p < 0.001) appeared as significant predictors of platelet enlargement in RMS in multiple linear regression analysis. CONCLUSIONS: Patients with RMS have increased platelet activity reflected as elevated MPV; and the coexistence of severe mitral regurgitation and presence of left atrial spontaneous echo contrast are determinants of this increment.
No takes yet. Share an insight, caveat, or question.
İleri et al. (2014) conducted a cross-sectional in Rheumatic mitral stenosis (n=116). Rheumatic mitral stenosis vs. Healthy subjects was evaluated on Mean platelet volume (MPV) (p=<0.001). Patients with rheumatic mitral stenosis had significantly higher mean platelet volume compared to healthy subjects (10.07 vs 8.15 fL, p < 0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: