Key result
Normally functioning BAV is linked to higher mean platelet volume versus healthy controls.
Why the study?
Is mean platelet volume increased in patients with normally functioning bicuspid aortic valve compared to healthy controls?
Case-Control (n=64)
Is mean platelet volume increased in patients with normally functioning bicuspid aortic valve compared to healthy controls?
Absolute Event Rate: 8.6% vs 8%
p-value: p=0.01
Patients with normally functioning bicuspid aortic valves have elevated mean platelet volume, suggesting increased platelet activation even in the absence of significant stenosis or regurgitation.
Suggests platelet activation in normally functioning BAV; hypothesis-generating and should not yet change practice.
BACKGROUND: It has been demonstrated that platelet activation occurs in patients with aortic stenosis. However, no study has assessed platelet activation in patients with a normally functioning bicuspid aortic valve (BAV). Therefore, we aimed to investigate relationship between platelet activation assessed by mean platelet volume (MPV) and normally functioning BAV. METHODS: Thirty-nine patients with isolated BAV and 25 age- and gender-matched healthy participants were included in the study. Patients with more than mild aortic regurgitation and aortic velocity >2 m/s were excluded from the study. For the entire study population, MPV was measured using an automatic blood counter. RESULTS: Compared to control group, MPV value was significantly higher in patients with BAV (8.6 ± 1.0 vs 8.0 ± 0.8, p: .01). In the correlation analysis, there was a significant correlation between MPV measures with aortic stiffness (r: .32 and p: .01) and aortic elastic modulus (r: .37 and p: .003). CONCLUSION: Our study results indicate that BAV is associated with elevated MPV values.
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Bilen et al. (2011) conducted a case-control in Bicuspid Aortic Valve (n=64). Bicuspid aortic valve vs. Healthy participants was evaluated on Mean platelet volume (MPV) (p=0.01). Normally functioning bicuspid aortic valve was associated with significantly higher mean platelet volume compared to healthy controls (8.6 ± 1.0 vs 8.0 ± 0.8, p=0.01).
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