Key result
Review outlines strengths and limitations of current animal models for acute and chronic right heart failure.
Why the study?
Solid animal models mimicking human pathophysiology are needed to understand right heart failure and develop targeted therapies, but selecting the right model is challenging due to the plethora of available options.
Population
Animal models of acute and chronic right heart failure in small and large animals
Design
Review
Authors
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May guide preclinical model selection for right heart failure; leaves optimal clinical translation open.
This review provides a comprehensive overview of animal models for right heart failure to aid researchers in selecting appropriate models for preclinical studies.
Andersen et al. (2020) conducted a review in Right heart failure. Animal models of right heart failure was evaluated. This review provides a comprehensive overview of the available animal models for acute and chronic right heart failure, detailing their specific strengths and limitations for preclinical research.
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