Key result
Childhood obesity is linked to ~41% higher LVMI and impaired diastolic function.
Why the study?
Emerging data indicate that cardiovascular effects of obesity can be evident in childhood, prompting evaluation of early left ventricular structural and functional changes and their anthropometric and biochemical associations in obese normotensive children.
Does obesity alter left ventricular structure and diastolic function in normotensive prepubertal children?
Cross-Sectional (n=62)
No
Does obesity alter left ventricular structure and diastolic function in normotensive prepubertal children?
Absolute Event Rate: 40.05% vs 28.31%
p-value: p=<0.05
Obesity in normotensive prepubertal children is associated with early subclinical changes in left ventricular geometry and diastolic function, which correlate with central adiposity and inflammation.
Alerts to possible early cardiac changes in obese normotensive children; extends observational data but requires prospective confirmation.
Εmerging data indicate that various effects of obesity on the cardiovascular system can be evident during childhood. The aim of this study was to detect early changes in left ventricular structure and function in obese normotensive children and explore possible associations of these changes with anthropometric and biochemical parameters. Normotensive 8-11-year-old obese and normal weight children were included in the study. They all underwent anthropometric measurements, laboratory tests, and echocardiography study by conventional and tissue Doppler to assess geometric pattern and function of left ventricle. Statistically significant differences in most anthropometric and metabolic parameters were noticed between groups. Obese children showed higher left ventricular mass index (LVMI) (40.05 ± 9.44 vs. 28.31 ± 6.22), lower E/A ratio (1.76 ± 0.33 vs. 2.08 ± 0.56), and higher E/e' (6.04 ± 1.13 vs. 5.43 ± 0.96) compared to lean peers. Waist-to-height ratio and hs-CRP correlated significantly with E/A in the obese group. Left ventricular hypertrophy was present in 47.2% of obese children and eccentric was the prominent type. Waist-to-height ratio and serum cortisol levels in plasma increased the odds of having any type of abnormal ventricular geometric pattern. Echocardiographic evaluation of left ventricle and diastolic function could be considered for obese normotensive children based on waist-to-height ratio, hs-CRP, and serum cortisol.
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Giannisi et al. (2020) conducted a cross-sectional in Childhood obesity (n=62). Obesity vs. Normal weight was evaluated on Left ventricular mass index (LVMI) (p=<0.05). Obese normotensive prepubertal children exhibited significantly higher left ventricular mass index (40.05 vs 28.31) and impaired diastolic function compared to normal-weight peers.
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