What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Childhood obesity (n=681). Intervention: Obesity (BMI z-score > 2) vs. Non-obese (BMI z-score ≤ 2). Primary outcome: Prevalence of left ventricular hypertrophy (LVH) (p=<0.001).

June 22, 2021Scientific ReportsOpen Access

The impact of obesity on left ventricular hypertrophy and diastolic dysfunction in children and adolescents

Q: What are the key findings of this study?

Childhood obesity was associated with a significantly higher prevalence of left ventricular hypertrophy (14.0% vs 3.6%) and increased left ventricular filling pressures compared to non-obese peers.

Q: What does this research mean for the field?

Childhood obesity is associated with a significantly higher prevalence of left ventricular hypertrophy and increased left ventricular filling pressures compared to non-obese peers. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

View Full Paper

Ask AI

Bookmark

Key result

Childhood obesity linked to ~4-fold higher LVH prevalence and increased filling pressures vs non-obese peers.

P<0.001
n=681

Why the study?

Childhood obesity continues to escalate worldwide and may affect left ventricular geometry and function.

Does obesity increase the prevalence of left ventricular hypertrophy and diastolic dysfunction in children and adolescents?

Population

681 children aged 5 to 16 years from randomly selected schools in Peru

Comparison

Obesity (body mass index z-score > 2) vs absence of obesity

Design

Analysis of prospectively collected cross-sectional data

Authors

JBJoanna BartkowiakInterventional Cardiology ESErnest SpitzerInterventional / Structural Cardiology RKReto KurmannCardio-Oncology

Discussion

Member takes

Implication

May support cardiac screening in obese youth; cross-sectional data leave causality and intervention effects open.

Study Design

Type

Cross-Sectional (n=681)

Multicenter

Yes

Structured PICO

Does obesity increase the prevalence of left ventricular hypertrophy and diastolic dysfunction in children and adolescents?

Population

681 children aged 5 to 16 years (mean age 12.2 ± 3.1 years, 50.1% male) from randomly selected schools in Arequipa, Peru. Excluded: structural heart defects, more than mild valvular lesions, missing height/weight, or missing echocardiographic parameters.

Intervention

Obesity (defined by body mass index z-score > 2)

Comparator

Non-obese (defined by body mass index z-score ≤ 2)

Outcome

Prevalence of left ventricular hypertrophy (LVH) and diastolic dysfunction (assessed using mitral inflow early-to-late diastolic flow (E/A) ratio, peak early diastolic tissue velocities of the lateral mitral annulus (E′), E/E′ ratio, and left atrial volume index (LAVI))surrogate

Main Result

Absolute Event Rate: 14% vs 3.6%

p-value: p=<0.001

Childhood obesity is associated with structural and functional cardiac changes, including left ventricular hypertrophy and early signs of diastolic dysfunction, highlighting the need for early lifestyle interventions.

Limitations

No standard definition of diastolic dysfunction in children and adolescents
One third of children excluded due to missing echocardiographic data, potentially introducing selection bias
E' measured at the lateral mitral annulus only, which may have led to underestimation of LV filling pressures
Blood pressure was not prospectively recorded
Reproducibility testing is not available
Children were not screened for disorders of the endocrine system or chromosomal disorders
Cross-sectional survey design precludes longitudinal assessment
E′ was measured at the lateral mitral annulus only, which may have led to an underestimation of LV filling pressures
Cross-sectional design lacks longitudinal data to delineate the risk of transition to HFpEF

Cite This Study

Bartkowiak et al. (2021) conducted a cross-sectional in Childhood obesity (n=681). Obesity (BMI z-score > 2) vs. Non-obese (BMI z-score ≤ 2) was evaluated on Prevalence of left ventricular hypertrophy (LVH) (p=<0.001). Childhood obesity was associated with a significantly higher prevalence of left ventricular hypertrophy (14.0% vs 3.6%) and increased left ventricular filling pressures compared to non-obese peers.

synapsesocial.com/papers/6a143edf40803be22f894d62 https://doi.org/10.1038/s41598-021-92463-x

View Full Paper

Ask AI

Bookmark

The impact of obesity on left ventricular hypertrophy and diastolic dysfunction in children and adolescents

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

The impact of obesity on left ventricular hypertrophy and diastolic dysfunction in children and adolescents

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Also Consider

Also Consider