What is the clinical evidence from this study?

Study design: Observational. Population: Idiopathic ventricular arrhythmias (n=135). Intervention: Radiofrequency catheter ablation vs. Failed ablation. Primary outcome: Normalization of high BNP concentration after ablation (p=<0.0005).

What does this research mean for the field?

Elevated plasma BNP normalizes in a majority (61%) of patients following successful radiofrequency catheter ablation for idiopathic ventricular arrhythmias, whereas it fails to normalize in patients with unsuccessful ablations. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

December 1, 2006Pacing and Clinical Electrophysiology

Significance and Utility of Plasma Brain Natriuretic Peptide Concentrations in Patients with Idiopathic Ventricular Arrhythmias

Q: What are the key findings of this study?

Elevated plasma BNP normalized in 61% of patients following successful radiofrequency catheter ablation for idiopathic ventricular arrhythmias, vs 0% with failed ablation (P<0.0005).

Q: What does this research mean for the field?

Elevated plasma BNP normalizes in a majority (61%) of patients following successful radiofrequency catheter ablation for idiopathic ventricular arrhythmias, whereas it fails to normalize in patients with unsuccessful ablations. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

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Key result

Elevated plasma BNP normalized in 61% of patients following successful radiofrequency catheter ablation for idiopathic ventricular arrhythmias, vs 0% with failed ablation (P<0.0005).

Why the study?

Does plasma BNP concentration correlate with the origin of idiopathic ventricular arrhythmias and indicate successful radiofrequency catheter ablation?

Population

135 patients with symptomatic, monomorphic idiopathic ventricular arrhythmias without structural heart…

Design

Cohort

Authors

HTHiroshi TadaElectrophysiology SISachiko ItoGunma University GSGoro ShinboDokkyo Medical University

Discussion

Member takes

Implication

BNP normalization may mark successful ablation in idiopathic VA; hypothesis-generating and requires prospective validation before clinical use.

Study Design

Type

Observational (n=135)

Structured PICO

Does plasma BNP concentration correlate with the origin of idiopathic ventricular arrhythmias and indicate successful radiofrequency catheter ablation?

Population

135 patients with symptomatic, monomorphic idiopathic ventricular arrhythmias (I-VT/PVCs) without structural heart disease or renal dysfunction (73 women; mean age 53 +/- 17 years; 50 ventricular tachycardias, 85 premature ventricular contractions) who underwent radiofrequency catheter ablation.

Intervention

Radiofrequency catheter ablation and measurement of plasma BNP concentration

Outcome

Plasma BNP concentration and its association with arrhythmia origin, patient characteristics, and ablation successsurrogate

Main Result

Absolute Event Rate: 61% vs 0%

p-value: p=<0.0005

Plasma BNP is frequently elevated in patients with idiopathic ventricular arrhythmias, particularly those of left ventricular origin, and its normalization may serve as a marker of successful catheter ablation.

Cite This Study

Tada et al. (2006) conducted an observational in Idiopathic ventricular arrhythmias (n=135). Radiofrequency catheter ablation vs. Failed ablation was evaluated on Normalization of high BNP concentration after ablation (p=<0.0005). Elevated plasma BNP normalized in 61% of patients following successful radiofrequency catheter ablation for idiopathic ventricular arrhythmias, vs 0% with failed ablation (P<0.0005).

synapsesocial.com/papers/6a1c8f60107ed6dc7cc3fc9b https://doi.org/10.1111/j.1540-8159.2006.00553.x

Topics

Ventricular arrhythmias

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December 1, 2006Pacing and Clinical Electrophysiology

Significance and Utility of Plasma Brain Natriuretic Peptide Concentrations in Patients with Idiopathic Ventricular Arrhythmias

View Full Paper

Ask AI

Bookmark

Key result

Elevated plasma BNP normalized in 61% of patients following successful radiofrequency catheter ablation for idiopathic ventricular arrhythmias, vs 0% with failed ablation (P<0.0005).

Why the study?

Does plasma BNP concentration correlate with the origin of idiopathic ventricular arrhythmias and indicate successful radiofrequency catheter ablation?

Population

135 patients with symptomatic, monomorphic idiopathic ventricular arrhythmias without structural heart…

Design

Cohort

Authors

HTHiroshi TadaElectrophysiology SISachiko ItoGunma University GSGoro ShinboDokkyo Medical University

Discussion

Member takes

Implication

BNP normalization may mark successful ablation in idiopathic VA; hypothesis-generating and requires prospective validation before clinical use.

Study Design

Type

Observational (n=135)

Structured PICO

Does plasma BNP concentration correlate with the origin of idiopathic ventricular arrhythmias and indicate successful radiofrequency catheter ablation?

Population

Intervention

Radiofrequency catheter ablation and measurement of plasma BNP concentration

Outcome

Plasma BNP concentration and its association with arrhythmia origin, patient characteristics, and ablation successsurrogate

Main Result

Absolute Event Rate: 61% vs 0%

p-value: p=<0.0005

Cite This Study

synapsesocial.com/papers/6a1c8f60107ed6dc7cc3fc9b https://doi.org/10.1111/j.1540-8159.2006.00553.x

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

Topics

Ventricular arrhythmias

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