Key result
Amplification of intrinsic electrical heterogeneities provides the substrate for Phase 2 and circus movement reentry, which underlie ventricular tachycardia in long QT and Brugada syndromes.
This review outlines the basic mechanisms of reentrant arrhythmias, highlighting the role of intrinsic electrical heterogeneities in long QT and Brugada syndromes.
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Highlights reentry substrates in LQTS/Brugada; leaves open whether targeting heterogeneities improves outcomes.
Charles Antzelevitch (2001) conducted a review in Cardiac arrhythmias. Amplification of intrinsic electrical heterogeneities provides the substrate for Phase 2 and circus movement reentry, which underlie ventricular tachycardia in long QT and Brugada syndromes.
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