Key result
Central obesity, but not overall obesity, was significantly associated with a higher prevalence of obstructive coronary artery disease in postmenopausal women (OR 1.61; 95% CI 1.10-2.34; P=0.013).
Why the study?
This study investigated the association between obesity type and obstructive coronary artery disease in postmenopausal women.
Is central or overall obesity associated with obstructive coronary artery disease in postmenopausal women with stable chest pain?
Observational (n=659)
Yes
Is central or overall obesity associated with obstructive coronary artery disease in postmenopausal women with stable chest pain?
Effect estimate: OR 1.61 (95% CI 1.10-2.34)
Absolute Event Rate: 55.5% vs 41%
p-value: p=0.013
In postmenopausal women with stable chest pain, central obesity (waist circumference ≥85 cm) is a significant predictor of obstructive CAD, whereas overall obesity (BMI ≥25) is not.
Central obesity may refine obstructive CAD risk stratification in postmenopausal women with stable chest pain; hypothesis-generating and should not yet change practice.
OBJECTIVES: This study investigated the association between obesity type and obstructive coronary artery disease (CAD) in postmenopausal women. METHODS: Study data were obtained from a nation-wide registry, composed of 659 women older than 55 years with chest pain undergoing elective invasive coronary angiography in the suspicion of CAD. Obstructive CAD was defined as angiographic findings of ≥50% diameter stenosis with any major epicardial coronary artery. Overall obesity was defined as a body mass index of ≥25 kg/m, and central obesity was defined as a waist circumference of ≥85 cm. RESULTS: A total of 311 women (47.2%) had obstructive CAD. The incidence of overall obesity was not different between participants with and without obstructive CAD (P = 0.340), but the prevalence of obstructive CAD was significantly higher in participants with central obesity than those without (55.5% vs 41.0%, P < 0.001). There was no significant difference in body mass index between participants with and without obstructive CAD (P = 0.373). Multivariable analysis showed that central obesity was associated with obstructive CAD even after controlling for potential confounders (odds ratio, 1.61; 95% confidence interval, 1.10-2.34; P = 0.013). However, overall obesity was not associated with obstructive CAD in the same multivariable analysis (P = 0.228). CONCLUSIONS: Central obesity but not overall obesity is associated with obstructive CAD in postmenopausal women with stable chest pain undergoing invasive coronary angiography. : Video Summary: Supplemental Digital Content 1, http://links.lww.com/MENO/A440.
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Cho et al. (2019) conducted an observational in Obstructive coronary artery disease (n=659). Central obesity vs. No central obesity was evaluated on Obstructive coronary artery disease (≥50% diameter stenosis) (OR 1.61, 95% CI 1.10-2.34, p=0.013). Central obesity, but not overall obesity, was significantly associated with a higher prevalence of obstructive coronary artery disease in postmenopausal women (OR 1.61; 95% CI 1.10-2.34; P=0.013).
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