Key result
Patient-specific modelling using CARDIOSIM© successfully simulated the haemodynamic effects of LVAD support, demonstrating its potential value as a quantitative tool for preoperative planning in advanced heart failure.
Why the study?
Does patient-specific computational simulation accurately model hemodynamic responses to LVAD support in advanced heart failure patients?
Case Report (n=3)
Does patient-specific computational simulation accurately model hemodynamic responses to LVAD support in advanced heart failure patients?
Patient-specific computational modeling can simulate hemodynamic responses to LVAD support, potentially aiding in preoperative planning and clinical decision-making for advanced heart failure patients.
Hypothesis-generating for simulation-guided LVAD planning; requires prospective validation before clinical adoption.
BACKGROUND: Modelling and simulation may become clinically applicable tools for detailed evaluation of the cardiovascular system and clinical decision-making to guide therapeutic intervention. Models based on pressure-volume relationship and zero-dimensional representation of the cardiovascular system may be a suitable choice given their simplicity and versatility. This approach has great potential for application in heart failure where the impact of left ventricular assist devices has played a significant role as a bridge to transplant and more recently as a long-term solution for non eligible candidates. RESULTS: was the software used for this purpose. The study was based on retrospective analysis of haemodynamic data previously discussed at a multidisciplinary meeting. The outcome of the simulations addressed the value of a more quantitative approach in the clinical decision process. CONCLUSIONS: Although previous experience, co-morbidities and the risk of potentially fatal complications play a role in clinical decision-making, patient-specific modelling may become a daily approach for selection and optimisation of device-based treatment for heart failure patients. Willingness to adopt this integrated approach may be the key to further progress.
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Capoccia et al. (2018) conducted a case report in Advanced heart failure (n=3). Simulation using CARDIOSIM© vs. Standard clinical decision-making was evaluated on Haemodynamic parameters (EDV, ESV, Ea/Ees ratio) during simulated LVAD support. Patient-specific modelling using CARDIOSIM© successfully simulated the haemodynamic effects of LVAD support, demonstrating its potential value as a quantitative tool for preoperative planning in advanced heart failure.
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