In Preeclampsia, Maternal Third Trimester Subcutaneous Adipocyte Lipolysis Is More Resistant to Suppression by Insulin Than in Healthy Pregnancy

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Why the study?

Is subcutaneous adipocyte lipolysis more resistant to suppression by insulin in preeclampsia compared to healthy pregnancy?

Structured PICO

Is subcutaneous adipocyte lipolysis more resistant to suppression by insulin in preeclampsia compared to healthy pregnancy?

Population

44 pregnant women undergoing caesarean section (n=31 healthy, n=13 preeclampsia)

Intervention

Assessment of subcutaneous and visceral adipose tissue biopsies (lipolysis in response to isoproterenol 200 nmol/L and insulin 10 nmol/L)

Comparator

Healthy pregnant women (n=31)

Outcome

Adipocyte lipolysis rates and insulin sensitivitysurrogate

In preeclampsia, subcutaneous adipocytes exhibit reduced insulin suppression of lipolysis, potentially increasing the burden of plasma fatty acids.

No takes yet. Share an insight, caveat, or question.

May worsen free fatty acid burden in preeclampsia; hypothesis-generating for adipocyte-targeted interventions.

Huda et al. (2014) studied this question.

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