Why the study?
Does combination angiotensin II receptor blockers plus angiotensin-converting enzyme inhibitors increase adverse effects compared to control treatment including ACE inhibitors in patients with symptomatic left ventricular dysfunction?
Population
17,337 patients from 4 RCTs with symptomatic left ventricular dysfunction
Comparison
Combination angiotensin II receptor blockers… vs Control treatment that included ACE inhibitors
Design
Meta-analysis
Follow-up
mean 25 months
Authors
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Supports avoiding dual ARB-ACEI therapy in symptomatic LV dysfunction; strengthens evidence against combination use.
Does combination angiotensin II receptor blockers plus angiotensin-converting enzyme inhibitors increase adverse effects compared to control treatment including ACE inhibitors in patients with symptomatic left ventricular dysfunction?
Combination therapy with ARBs and ACE inhibitors in patients with symptomatic left ventricular dysfunction significantly increases the risk of adverse effects such as worsening renal function, hyperkalemia, and symptomatic hypotension.
Phillips et al. (2007) studied this question.
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