December 30, 2010Journal of Cardiovascular Pharmacology and Therapeutics
Meta-Analysis of Renin-Angiotensin-Aldosterone Blockade for Heart Failure in Presence of Preserved Left Ventricular Function
Why the study?
Do ACE inhibitors or ARBs reduce hospitalization for heart failure or cardiovascular mortality in patients with heart failure and preserved LVEF?
Population
8,152 patients with heart failure and preserved left ventricular ejection fraction pooled from 4 randomized…
Comparison
Angiotensin-converting enzyme inhibitors or… vs Placebo or no treatment.
Design
Meta-analysis
Follow-up
1 year to prolonged follow-up
Authors
Discussion
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Implication
ACEi/ARB may reduce HF hospitalizations in HFpEF; confirms admission benefit but leaves CV mortality reduction open.
Structured PICO
Do ACE inhibitors or ARBs reduce hospitalization for heart failure or cardiovascular mortality in patients with heart failure and preserved LVEF?
P
Population
8,152 patients with heart failure and preserved left ventricular ejection fraction (LVEF) pooled from 4 randomized trials.
I
Intervention
Angiotensin-converting enzyme (ACE) inhibitors or angiotensin-II receptor blockers (ARB) (ACE inhibitors in 1 trial, ARB in 2 trials, both in 1 trial).
C
Comparator
Placebo or no treatment.
O
Outcome
Hospitalization for heart failure and cardiovascular mortality.hard clinical
In patients with HFpEF, ACE inhibitors or ARBs significantly reduce heart failure hospitalizations but do not improve cardiovascular mortality.
Cite This Study
Meune et al. (2010) studied this question.