Why the study?
Does continuous 12-hour infusion of an angiotensin II antagonist reduce mean arterial pressure in chronic renal hypertensive rabbits?
Population
34 conscious New Zealand white rabbits
Comparison
Continuous 12-hour infusion of a saline solution… vs Infusion of saline alone for 12 hours
Design
Preclinical
Follow-up
12 hours
Authors
Loading...
No BP reduction with angiotensin II antagonism in this rabbit model; leaves open alternative drivers of chronic renal hypertension and precludes clinical translation.
Does continuous 12-hour infusion of an angiotensin II antagonist reduce mean arterial pressure in chronic renal hypertensive rabbits?
Continuous infusion of an angiotensin II antagonist did not lower blood pressure in chronic renal hypertensive rabbits, suggesting angiotensin II is not the primary driver maintaining elevated pressure in this model.
Kurz et al. (1981) studied this question.