Why the study?
Does continuous 12-hour infusion of an angiotensin II antagonist reduce mean arterial pressure in chronic renal hypertensive rabbits?
Does continuous 12-hour infusion of an angiotensin II antagonist reduce mean arterial pressure in chronic renal hypertensive rabbits?
Continuous infusion of an angiotensin II antagonist did not lower blood pressure in chronic renal hypertensive rabbits, suggesting angiotensin II is not the primary driver maintaining elevated pressure in this model.
Answers are grounded in this paper and cite their sources.
No BP reduction with angiotensin II antagonism in this rabbit model; leaves open alternative drivers of chronic renal hypertension and precludes clinical translation.
The effect of a continuous 12-hour infusion of a saline solution of the angiotensin II antagonist, [Sar1, Ile8] angiotensin II, on mean arterial pressure was studied in 11 conscious New Zealand white rabbits with hypertension induced by renal artery stenosis and contralateral nephrectomy, and in 11 normotensive control rabbits. Also, the effect on mean arterial pressure of infusing saline alone for 12 hours was examined in 4 hypertensive rabbits and in 8 normotensive controls. There were no significant differences in the changes in mean arterial pressure among the 4 groups of rabbits at any hourly period during these infusions. These studies were unable to provide evidence that angiotensin II is involved in maintaining the elevated arterial pressure in this hypertensive animal model.
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Kurz et al. (1981) studied this question.
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