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December 19, 2025Cell Reports6 citationsOpen Access

Distinct precursor landscape of subcutaneous and visceral fat in development and aging

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Why the study?

In aging, pathogenic VAT tends to increase while protective SAT is significantly reduced, but the mechanism driving this depot-specific reduction in SAT is not well understood.

Comparison

Depot-specific adipose precursor populations in SAT vs VAT

Design

Review

Authors

FLFrances LinHSHei Sook Sul

Discussion

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Overview

Adipose precursor heterogeneity may shape age-related fat distribution; leaves open targeted interventions for cardiometabolic outcomes.

Structured PICO

P
Population
Adipose tissue precursors in subcutaneous and visceral fat during development and aging

This review highlights the distinct developmental origins and precursor heterogeneity of subcutaneous and visceral adipose tissue, particularly focusing on changes during aging.

Cite This Study

Lin et al. (2025) studied this question.

synapsesocial.com/papers/6a1d13bfba65f5ee325dbe72https://doi.org/10.1016/j.celrep.2025.116706
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