December 19, 2025Cell ReportsOpen Access

The review summarizes recent research on depot-specific adipose precursor heterogeneity in subcutaneous and visceral adipose tissue, and distinct precursor populations arising during aging that drive differential changes in adipose mass.

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Why the study?

In aging, pathogenic VAT tends to increase while protective SAT is significantly reduced, but the mechanism driving this depot-specific reduction in SAT is not well understood.

Comparison

Depot-specific adipose precursor populations in SAT vs VAT

Design

Review

Authors

FLFrances Lin HSHei Sook Sul

Discussion

Member takes

Overview

Adipose precursor heterogeneity may shape age-related fat distribution; leaves open targeted interventions for cardiometabolic outcomes.

Structured PICO

Population

Adipose tissue precursors in subcutaneous and visceral fat during development and aging

This review highlights the distinct developmental origins and precursor heterogeneity of subcutaneous and visceral adipose tissue, particularly focusing on changes during aging.

Cite This Study

Lin et al. (2025) studied this question.

synapsesocial.com/papers/6a1d13bfba65f5ee325dbe72 https://doi.org/10.1016/j.celrep.2025.116706

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December 19, 2025Cell ReportsOpen Access

The review summarizes recent research on depot-specific adipose precursor heterogeneity in subcutaneous and visceral adipose tissue, and distinct precursor populations arising during aging that drive differential changes in adipose mass.

View Full Paper

Ask AI

Bookmark

Why the study?

In aging, pathogenic VAT tends to increase while protective SAT is significantly reduced, but the mechanism driving this depot-specific reduction in SAT is not well understood.

Comparison

Depot-specific adipose precursor populations in SAT vs VAT

Design

Review

Authors

FLFrances Lin HSHei Sook Sul

Discussion

Member takes

Overview

Adipose precursor heterogeneity may shape age-related fat distribution; leaves open targeted interventions for cardiometabolic outcomes.

Structured PICO

Population

Adipose tissue precursors in subcutaneous and visceral fat during development and aging

This review highlights the distinct developmental origins and precursor heterogeneity of subcutaneous and visceral adipose tissue, particularly focusing on changes during aging.

Cite This Study

Lin et al. (2025) studied this question.

synapsesocial.com/papers/6a1d13bfba65f5ee325dbe72 https://doi.org/10.1016/j.celrep.2025.116706

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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