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January 1, 2012The Journal of Physical Fitness and Sports MedicineOpen Access

Recent advances in the adaptations of adipose tissue to physical activity: Morphology and adipose tissue cellularity

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Key result

Exercise training may attenuate increases in adipocyte number by suppressing adipogenic differentiation and up-regulating hypoxia-inducible factor-1α, while maintaining endothelial cell density.

Design

Review

Authors

TITetsuya IzawaJOJunetsu OgasawaraTSTakuya Sakurai

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Overview

May guide exercise for adipose remodeling; leaves open clinical outcome trials in obesity.

Structured PICO

E
Exposure
Exercise training
O
Outcome
Morphology of white adipose tissue and adipose tissue cellularity

This review summarizes the molecular and cellular adaptations of white adipose tissue to exercise training, highlighting changes in adipocyte number and gene expression.

Limitations

  • It remains unclear whether developmental and patterning genes are associated with morphological changes in white adipose tissue in response to exercise training.
  • It is debatable whether the various adaptations of white adipose tissue to exercise training are mediated by a negative energy balance or elicited by the effects of training per se.

Cite This Study

Izawa et al. (2012) conducted a review in Adipose tissue adaptation to physical activity. Exercise training was evaluated. Exercise training may attenuate increases in adipocyte number by suppressing adipogenic differentiation and up-regulating hypoxia-inducible factor-1α, while maintaining endothelial cell density.

synapsesocial.com/papers/6ab0ea176ceb9157b3ec4f45https://doi.org/10.7600/jpfsm.1.381
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Exercise-induced adaptations to white and brown adipose tissue2018 · 121 citations
  2. 2Current Progress in Adipose Tissue Biology: Implications in Obesity and Its Comorbidities2020 · 4 citations
  3. 3Structural and biochemical characteristics of various white adipose tissue depots2012 · 374 citations
  4. 4Exercise Effects on White Adipose Tissue: Beiging and Metabolic Adaptations2015 · 339 citations
  5. 5Is adipose tissue metabolically different at different sites?2011 · 111 citations