What does this research mean for the field?

Acetylcholine-induced vasodilation in the abdominal aorta during pregnancy is mediated only partly by nitric oxide, with the remainder driven by a cytochrome P450-dependent endothelium-derived vasodilator, likely endothelium-derived hyperpolarizing factor (EDHF). Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

September 1, 1997Hypertension

Possible Involvement of Endothelium-Derived Hyperpolarizing Factor in Vascular Responses of Abdominal Aorta From Pregnant Rats

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Population

Thoracic and abdominal aortic rings from pregnant and nonpregnant Wistar-Kyoto rats

Comparison

Acetylcholine with or without inhibitors vs Aortic rings from nonpregnant rats

Design

Preclinical

Authors

RBRosa A. Bobadilla-LugoInstituto Politécnico Nacional CHCarlos Castillo HenkelInstituto Politécnico Nacional ECEnrique F. CastilloUniversity of New Mexico

Discussion

Member takes

Implication

Supports EDHF mediation of enhanced aortic relaxation in pregnant rats; leaves open translation to human gestational hemodynamics.

Structured PICO

Population

Thoracic and abdominal aortic rings from pregnant and nonpregnant Wistar-Kyoto rats

Intervention

Acetylcholine with or without inhibitors (L-NAME, indomethacin, clotrimazole)

Comparator

Aortic rings from nonpregnant rats

Outcome

Acetylcholine-induced relaxation and release of nitritessurrogate

Acetylcholine-induced vasodilation in the abdominal aorta of pregnant rats is partially mediated by a cytochrome P450-dependent endothelium-derived hyperpolarizing factor.

Cite This Study

Bobadilla-Lugo et al. (1997) studied this question.

synapsesocial.com/papers/6a1d155d5b7fddc35204cdfa https://doi.org/10.1161/01.hyp.30.3.596

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Possible Involvement of Endothelium-Derived Hyperpolarizing Factor in Vascular Responses of Abdominal Aorta From Pregnant Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Possible Involvement of Endothelium-Derived Hyperpolarizing Factor in Vascular Responses of Abdominal Aorta From Pregnant Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider