Key result
Pregnancy enhances endothelium-dependent vasodilation in rats, reducing required acetylcholine by ~84%.
Population
Small, isometrically mounted mesenteric arteries from virgin and gravid rats
Comparison
Pregnancy (gravid state) vs Virgin state
Design
Preclinical
Authors
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Hypothesis-generating for gestational vascular adaptations in rodents; leaves open translation to human pregnancy physiology.
Absolute Event Rate: 0.04% vs 0.25%
Pregnancy enhances ACh-induced nitric oxide release in rat mesenteric microvessels while inhibiting a NO-independent vasodilator.
Pascoal et al. (1995) studied Pregnancy. Pregnancy (gravid state) vs. Virgin state was evaluated on Acetylcholine-induced endothelium-dependent vasodilation (half-maximum effective concentration in microM). Pregnancy enhanced acetylcholine-induced endothelium-dependent vasodilation in mesenteric microvessels (half-maximum effective concentration 0.04 vs 0.25 microM in gravid vs virgin rats).
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