What does this research mean for the field?

Pregnancy differentially alters vascular reactivity in guinea pigs by increasing acetylcholine-induced relaxation and sensitivity to U-46619-induced contraction in mesenteric arteries while producing no such changes in renal arteries. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

July 1, 1994AJP Heart and Circulatory Physiology

Effect of pregnancy on contraction and endothelium-mediated relaxation of renal and mesenteric arteries

Q: What is the clinical evidence from this study?

Study design: Other. Population: Pregnancy (animal model). Intervention: Pregnancy vs. Nonpregnant state. Primary outcome: Vascular reactivity (relaxation to ACh and contraction to U-46619) in mesenteric and renal arteries.

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Key result

Pregnancy increases mesenteric but not renal artery relaxation and contraction sensitivity in guinea pigs.

Authors

TKT. H. KimDong-A University CWCarl P. WeinerCreighton University LTLoren P. ThompsonUniversity of Vermont

Discussion

Member takes

Implication

Does not support changes in clinical management; leaves open regional vascular adaptations during human pregnancy.

PICO

Population

Pregnant and nonpregnant guinea pigs used to investigate vascular reactivity in mesenteric and renal arteries.

Exposure / Comparator

Pregnancy vs Nonpregnant state

Primary Outcome

Vascular reactivity (relaxation to ACh and contraction to U-46619) in mesenteric and renal arteries

Cite This Study

Kim et al. (1994) studied Pregnancy (animal model). Pregnancy vs. Nonpregnant state was evaluated on Vascular reactivity (relaxation to ACh and contraction to U-46619) in mesenteric and renal arteries. Pregnancy increased acetylcholine-stimulated relaxation and reduced the threshold concentration for U-46619 contraction in mesenteric arteries, but had no effect on renal arteries in guinea pigs.

synapsesocial.com/papers/6aa7922ffb78d07897efffa9 https://doi.org/10.1152/ajpheart.1994.267.1.h41

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Effect of pregnancy on contraction and endothelium-mediated relaxation of renal and mesenteric arteries

Discussion

Member takes

Implication

PICO

Cite This Study

Effect of pregnancy on contraction and endothelium-mediated relaxation of renal and mesenteric arteries

Discussion

Member takes

Implication

PICO

Cite This Study

Also Consider

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