October 1, 1991AJP Heart and Circulatory Physiology

Effect of pregnancy on endothelium and smooth muscle: their role in reduced adrenergic sensitivity

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Population

Isolated rings of uterine and carotid arteries from pregnant and nonpregnant guinea pigs

Comparison

Pharmacological agents including A23187, sodium… vs Arteries from nonpregnant guinea pigs

Design

Preclinical

Authors

CWCarl P. WeinerUniversity of Kansas Medical Center KLK. Z. LiuSoochow University LTLoren P. ThompsonUniversity of Vermont

Discussion

Member takes

Implication

Implicates EDRF in gestational uterine hyporesponsiveness in guinea pigs; hypothesis-generating for human pregnancy hemodynamics.

Structured PICO

Population

Isolated rings of uterine and carotid arteries from pregnant and nonpregnant guinea pigs

Intervention

Pharmacological agents including A23187, sodium nitroprusside, norepinephrine, indomethacin, methylene blue, and N-monomethyl-L-arginine

Comparator

Arteries from nonpregnant guinea pigs

Outcome

Vascular reactivity (relaxation and contraction responses)surrogate

Endothelium-derived relaxing factor (EDRF) synthesis appears responsible for the decreased uterine artery sensitivity to norepinephrine during pregnancy in guinea pigs.

Cite This Study

Weiner et al. (1991) studied this question.

synapsesocial.com/papers/6a6f918c8031ec7bb1dbd2e1 https://doi.org/10.1152/ajpheart.1991.261.4.h1275

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Effect of pregnancy on endothelium and smooth muscle: their role in reduced adrenergic sensitivity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effect of pregnancy on endothelium and smooth muscle: their role in reduced adrenergic sensitivity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider