What does this research mean for the field?

Q: What does this research mean for the field?

Endothelium-derived nitric oxide, acting through the NO-sensitive guanylate cyclase pathway and cGMP formation, supports the recruitment of renin-expressing cells along preglomerular vessels during chronic renin-angiotensin system stimulation. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 8, 2013HypertensionOpen Access

Endothelium-Derived Nitric Oxide Supports Renin Cell Recruitment Through the Nitric Oxide–Sensitive Guanylate Cyclase Pathway

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Population

Wild-type mice, mice lacking endothelial NO synthase, and mice lacking NO-sensitive guanylate cyclase in…

Comparison

Low-salt diet in combination with the ACE… vs Wild-type mice vs knockout mice, and wild-type…

Design

Preclinical

Follow-up

3 weeks

Authors

BNBjörn NeubauerUniversity of Freiburg KMKatharina MachuraUniversity of Regensburg RKRamona KettlUniversity of Würzburg

Discussion

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Implication

Animal data link endothelial NO to renin cell recruitment; leaves open relevance to human hypertension or RAS modulation.

Structured PICO

Population

Wild-type mice, mice lacking endothelial NO synthase, and mice lacking NO-sensitive guanylate cyclase in renin-expressing cells and preglomerular smooth muscle cells

Intervention

Low-salt diet in combination with the ACE inhibitor enalapril for 3 weeks, with or without the nonselective NO synthase inhibitor L-NAME

Comparator

Wild-type mice vs knockout mice, and wild-type mice with vs without L-NAME

Outcome

Recruitment of renin-producing cells in afferent arterioles and hypertrophy of the juxtaglomerular apparatussurrogate

Endothelium-derived NO acts via NO-sensitive guanylate cyclase to support the recruitment of renin-expressing cells along preglomerular vessels during chronic renin-angiotensin system stimulation.

Cite This Study

Neubauer et al. (2013) studied this question.

synapsesocial.com/papers/6a1d180b73c56dd1bd2f280b https://doi.org/10.1161/hypertensionaha.111.00221

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Endothelium-Derived Nitric Oxide Supports Renin Cell Recruitment Through the Nitric Oxide–Sensitive Guanylate Cyclase Pathway

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Endothelium-Derived Nitric Oxide Supports Renin Cell Recruitment Through the Nitric Oxide–Sensitive Guanylate Cyclase Pathway

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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