Population
Isolated, perfused rat thick ascending limbs, tubules from mice lacking NOS 3, and primary cultures of thick…
Comparison
Application of shear stress via increased… vs Absence of flow/shear stress, or application of…
Design
Preclinical
Authors
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Supports shear stress as primary driver of flow-induced NO in TAL; leaves open translation to human renal physiology or disease.
Shear stress, rather than pressure, stretch, or ion delivery, is the primary mechanical force mediating flow-induced nitric oxide production by NOS 3 in thick ascending limbs.
Cabral et al. (2010) studied this question.
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