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March 1, 1994AJP Cell Physiology

Role of calcium and calmodulin in flow-induced nitric oxide production in endothelial cells

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Population

Cultured endothelial cells (EC)

Comparison

Exposure to well-defined laminar fluid flow vs Preexisting flow level and bradykinin-mediated…

Design

Preclinical

Authors

MKMatthew J. KuchanAbbott (United Kingdom)JFJohn A. FrangosLa Jolla Bioengineering Institute

Discussion

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Implication

Sustained flow-induced NO production is calcium/calmodulin-independent in endothelial cells; extends in vitro mechanotransduction insights but leaves open in vivo relevance.

Structured PICO

P
Population
Cultured endothelial cells (EC)
I
Intervention
Exposure to well-defined laminar fluid flow
C
Comparator
Preexisting flow level and bradykinin (BK)-mediated NO production
O
Outcome
Nitric oxide (NO) production (monitored by release of NOx and cellular cGMP concentration)surrogate

Sustained shear stress-mediated nitric oxide production in endothelial cells is independent of calcium and calmodulin, distinguishing it from the initial rapid response to flow.

Cite This Study

Kuchan et al. (1994) studied this question.

synapsesocial.com/papers/6a730d2f8ca63dee9860e47dhttps://doi.org/10.1152/ajpcell.1994.266.3.c628
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Calmodulin-dependent endothelium-derived relaxing factor/nitric oxide synthase activity is present in the particulate and cytosolic fractions of bovine aortic endothelial cells.1991 · 595 citations
  2. 2Flow Effects on Prostacyclin Production by Cultured Human Endothelial Cells1985 · 1,240 citations
  3. 3Flow-dependent dilation in a resistance artery still occurs after endothelium removal.1988 · 56 citations
  4. 4Shear stress-induced release of nitric oxide from endothelial cells grown on beads.1991 · 486 citations
  5. 5Flow activates an endothelial potassium channel to release an endogenous nitrovasodilator.1991 · 538 citations