February 1, 1998AJP Heart and Circulatory Physiology

Nitric oxide production by cultured human aortic smooth muscle cells: stimulation by fluid flow

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Population

Cultured human aortic smooth muscle cells (SMC)

Comparison

Exposure to fluid flow vs Static conditions

Design

Preclinical

Authors

MPMaria PapadakiLoyola University Chicago RTRonald G. TiltonThe University of Texas Medical Branch at Galveston SESuzanne G. EskinGeorgia Institute of Technology

Discussion

Member takes

Implication

Indicates constitutive nNOS in aortic SMCs produces flow-stimulated NO; leaves open in vivo vascular relevance.

Structured PICO

Population

Cultured human aortic smooth muscle cells (SMC)

Intervention

Exposure to fluid flow (shear stress 1.1-25 dyn/cm2)

Comparator

Static conditions

Outcome

Nitric oxide (NO) production (monitored by nitrite and guanosine 3',5'-cyclic monophosphate production)surrogate

Human aortic smooth muscle cells express a constitutive neuronal NOS isoform whose enzymatic activity is modulated by fluid flow to produce nitric oxide.

Cite This Study

Papadaki et al. (1998) studied this question.

synapsesocial.com/papers/6a826522a8461dff0846cd47 https://doi.org/10.1152/ajpheart.1998.274.2.h616

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